7. QB Alex Smith, KC

Smith is similar to Manning in that he’s an expert play caller who knows his offense well, and is backed by a fearsome defense. With Jamaal Charles out for the majority of the season, Smith completed 65.3 percent of his passes for 3,486 yards, 20 touchdowns and seven interceptions, while also rushing for 498 yards (5.9 ypc) and two touchdowns.

The addition of Jeremy Maclin ceratinly helped, as Smith was finally able to break his embarrassing streak of 21 games without throwing a touchdown to a wide receiver. Andy Reid‘s run-heavy offensive scheme deserves just as much of the credit for this streak, however.

With Charles out, Reid will look to the most talked about waiver wire addition in fantasy football this season, Charcandrick West to handle most of the workload in the backfield. Though it may be Smith who is going to have to get the job done on Sunday as the running game may have a little trouble getting going against J.J. Watt and company.

The next guy on this list also comes from a run-heavy offense that lost their top running back to injuries. Now he’s being called upon to throw the ball more than ever.